Figure 9
Impact of AAV-mediated manipulation of hippocampal GM-CSFRα levels on spatial learning and memory.
(A) Learning curves during training were indistinguishable between groups (genotype*day p>0.05). (B) Area under the curve plot of spatial learning in the MWM (genotype p>0.05). (C) Accuracy of memory for the former platform location during the probe trial was dependent on hippocampal GM-CSFRα levels with an impairment and improvement caused by treatment with AAV-sh427 and AAV-GMCSFRα, respectively, as judged by the time spent in the target area. (*, p<0.05). n = 18 animals per group. Data is presented as mean ± SEM.
