Table 1 Pilot Clinical Findings in Melanoma

From: 12-Chemokine Gene Signature Identifies Lymph Node-like Structures in Melanoma: Potential for Patient Selection for Immunotherapy?

     

Therapy

Signaturea

TL-ELNs

Sample No.a

Tumor Location

Time (in months)b

None

Surgery

Chemoe

XRT

Other

+

+

112

Pancreas

180c,d

  

+

 

Ipi

+

+

115

Lung

114c,d

 

+

   

+

+

116

Lung

72c,d

 

+

 

+

 

+

+

113

Lung

72c

 

+

+

  

+

+

118

Pelvic soft tissue

65c

+

    

5

Liver

36

  

+

  

1

Brain

35

 

+

 

+

 

3

Brain

30

 

+

 

+

IFN

6

Skinf

13

 

+

   

7

Node

8

+

    
  1. aSee Figure 2c.
  2. bTime (in months) since primary melanoma to death or present date of evaluation.
  3. cp = 0.008 compared to signature − group (exact Wilcoxon rank sum test).
  4. dAlive as of May 1, 2012.
  5. eChemotherapy drugs included: carbo-taxol (1 patient), temozolomide (2 patients), liposomal cytarabine and sagopilone (1 patient each).
  6. fSubcutaneous metastasis.
  7. Abbreviations: Ipi, ipilimumab; IFN, interferon-alfa; XRT, external beam radiation therapy.