Figure 4
From: Digit patterning during limb development as a result of the BMP-receptor interaction
Free deformation of the domain according to the local concentration of FGF.
The FGF patterning gets split up at the positions of the digits due to the positive feedback of the BR2 complex on FGF. The domain can then be deformed by allowing growth normal to the surface according to the local concentration of FGF. The growth rate is equivalent to [FGF]4 × vg. (A–C) Expression of FGF on the boundary (i.e. 
) at different simulation times τ = 500, 1500 and 2500. (D) FGF8 expression pattern in mouse limb at E13.5; adapted from Fig. 2C in95; (E–G) The spatial distribution of the BR2 complex at τ = 500, 1500 and 2500. (H) Sox9 expression pattern in mouse limb buds at E13.5; adapted from Fig. 8M in104. Note that the rates of receptor and BMP degradation were increased by 10 percent relative to the standard values used.
