Figure 1 | Scientific Reports

Figure 1

From: Controlled intracellular self-assembly of gadolinium nanoparticles as smart molecular MR contrast agents

Figure 1

Shematic illustration of a furin-controlled condensation and self-assembly of Gd-NPs in cancer cells.

After entering cancer cells, the disulfide bond of probe 1 is reduced by GSH and the RVRR peptide sequence is cleaved by furin to yield the active intermediate 1-Core. Two 1-Cores condense to yield amphiphilic dimer 1-D which self-assembles into Gd-NPs at or near the locations of furin in cells (i.e., Golgi bodies).

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