Figure 1 | Scientific Reports

Figure 1

From: Novel Selective and Irreversible Mosquito Acetylcholinesterase Inhibitors for Controlling Malaria and Other Mosquito-Borne Diseases

Figure 1

New chemicals that target an insect-specific cysteine of AP-AChEs.

Upper left panel: cross-section of the AP-AChE and AChE active sites showing the locations of the insect-specific cysteine and the corresponding residue in non-insect species; upper right panel: chemical structures of PMn, PYn, PYS18 and PMS20; middle panel: two-step quiescent affinity labeling mechanism for PMn and PYn and definition of kinetic parameters; lower panel: syntheses of PMn, PYn, PYS18 and PMS20. DCM: CH2Cl2; DMF: N,N′-dimethylformamide; NBS: N-bromosuccinimide; TFA: CF3CO2; THF: tetrahydrofuran; : reflux.

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