Figure 5

Progressive AChE inhibition as a function of time and inhibitor concentration indicating the two-step quiescent affinity labeling mechanism for the test inhibitors.
% enzyme activity: the enzyme activity compared to that without inhibitor treatment. Left: linear plots of natural log of % AChE activity versus time in second at different inhibitor concentrations; right: nonlinear plots of the observed inhibition rate in 1/second versus inhibitor concentration in nanomolar.