Figure 5

Structural comparison between SP0498 Big domain and the typical Ca2+-binding modules.
SP0498 Big domain, upper left; crystallin domain of Methanosarcina acetivorans M-crystallin (PDB code 2K1W), upper right; C2 domain of rat Synaptogamin I (PDB code 1BYN), lower left; and EF-hand domain of human cardiac sodium channel NaV1.5 (PDB code 2KBI), lower right.