Figure 3 | Scientific Reports

Figure 3

From: Novel genetically-humanized mouse model established to evaluate efficacy of therapeutic agents to human interleukin-6 receptor

Figure 3

Spleen tissue of an Il6rahIL6R/hIL6R mouse (a, d), an Il6rahIL6R/hIL6R-hIL6 transgenic mouse (b, e) and a tocilizumab-treated Il6rahIL6R/hIL6R-hIL6 transgenic mouse (c, f).

Increase of plasma cells and increased numbers of white pulp in the Il6rahIL6R/hIL6R-hIL6 transgenic mouse (b, e) were ameliorated after 4-week treatment with tocilizumab (c, f). Plasma cells are shown in insert (b). Bars: (a–c), 100 μm; (d–f), 500 μm. W, white pulp.

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