Figure 4
Plasma levels of soluble hIL6R (a) and hIL6 (b) concentration after 4-week treatment with 0.1, 0.25 and 0.5 mg/body of TCZ in each genotype of mouse (n = 5 per group).
(a) Plasma soluble hIL6R concentrations were approximately 21 ng/ml in saline-treated Il6rahIL6R/hIL6R-hIL6 transgenic mice, whereas marked elevation of plasma soluble hIL6R levels, approximately 40–50 times higher than those of vehicle control, was observed after 4 weeks in TCZ-treated Il6rahIL6R/hIL6R-hIL6 transgenic mice. (b) Plasma hIL6 was detected at the level of 163 pg/ml in saline-treated Il6rahIL6R/hIL6R-hIL6 transgenic mice, whereas the hIL6 levels were markedly elevated to the levels of 936–1204 pg/ml after 4-week treatment of TCZ. ND, not detected. Non Tg, hIL6 non-transgenic mice; Tg, hIL6 transgenic mice.
