Figure 1
From: Robust shifts in S100a9 expression with aging: A novel mechanism for chronic inflammation
Shifts in the expression of S100a8 and S100a9 are a robust feature of aging in human and mouse tissues (meta-analysis of microarray data).
The effects of aging on the expression of S100-encoding mRNAs were evaluated in human (left) and mouse (right) tissues. All human data was generated using the Affymetrix Human Genome U133 Plus 2.0 array platform (29 experiments) and all mouse data was generated using the Affymetrix Mouse Genome 430 2.0 array platform (34 experiments). Data were obtained from the Gene Expression Omnibus or ArrayExpress databases. Colors denote the estimated fold-change over 40 years in humans (left; old/young) or over 2 years in mice (right; old/young). Triangles denote significant effects of aging on the expression of the listed gene (row) with respect to the indicated tissue (column) (P < 0.05 or FDR < 0.05).
