Figure 3
From: Robust shifts in S100a9 expression with aging: A novel mechanism for chronic inflammation
Top-ranked transcription factor motifs that predict S100a9 coexpression (30 mouse cell types).
Top-ranked motifs are listed in the left margin and were selected based upon three criteria. First, we identified those motifs for which an increased number of occurrences significantly increased the probability of S100a9 coexpression in the composite network (i.e., lowest p-values in composite with Z > 0; left margin labels with black font). Second, we identified those motifs for which an increased number of occurrences significantly increased the probability of S100a9 coexpression across the largest total number of cell types (i.e., largest number of up-triangles per row; left margin labels with red font). Third, for the 10 cell types that most consistently expressed S100a9 above background in microarray samples (i.e., neutrophils, …, monocytes), we identified the single motif most significantly associated with S100a9 coexpression (i.e., lowest p-value for each cell type with Z > 0; left margin labels with blue font). Positive Z statistics (red heatmap colors) indicate that increased motif occurrence within 2 KB upstream regions was associated with increased probability of S100a9 coexpression. Negative Z statistics (green heatmap colors) indicate that decreased motif occurrence 2 KB upstream was associated with increased probability of S100a9 coexpression. For each cell type (columns), the percentage shown in parentheses is the fraction of microarray samples for which S100a9 was expressed above background.
