Figure 5

The region 150–250 BP upstream of the mouse S100a9 gene (mm9, chr3, 90499762–90499862) contains the highest concentration of TF binding sites that predict S100a9 coexpression.

For each cell type, the 2 KB region upstream of the S100a9 transcription start site was scanned for matches to the TF binding sites within our dictionary of 1209 motifs. If a match was identified, the matching region was assigned a cell-type-specific score (proportional to the Z statistic calculated for that motif and cell type), which quantified the degree to which increased motif occurrence increased the probability of S100a9 coexpression. If more than one motif matched at a given position, the highest score was assigned. A sliding window analysis was then used to identify regions with greatest concentration of high-scoring base pairs (dark grey = best 400 BP window; yellow = best 200 BP window; orange = best 100 BP window; red = best 50 BP window). The right margin (blue symbols) lists the individual motif, with at least one match 2 KB upstream, for which increased motif occurrence was most significantly associated with S100a9 coexpression (i.e., lowest p-value with Z > 0).