Figure 1 | Scientific Reports

Figure 1

From: Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6

Figure 1

Dose-dependent cytotoxicity of Tnv-6.

Compared to 5 μM or 1 μM, greater cytotoxicity to CLL cells was evident with 10 μM of Tnv-6 at 24 hours (n = 10, p = 0.005, Student's t-test on paired samples) and at equivalent levels to 3 μM fludarabine (a). Cytotoxicity with 10 μM Tnv-6 at 8 hours (relative to controls, p = 0.007,) was also similar to fludarabine-containing cultures (p = non-significant) (b).

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