Figure 2 | Scientific Reports

Figure 2

From: Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6

Figure 2

Human hematopoietic progenitor cell development (HPC) with Tnv-6.

Numbers of HPC recovered after 8 hours of culture of normal peripheral blood mononuclear cells with control medium (Control), Tnv-6 (10 μM) or fludarabine (3 μM). The recovery of HPC from Controls and cultures incubated with Tnv-6 was equivalent (p = 0.5), but higher than in fludarabine-containing cultures (p < 0.05, Student's t-test on paired samples), suggesting that the anti-leukemic dose of Tnv-6 is non-toxic to human HPC in vitro.

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