Table 1 Fold-change in autophagy-lysosomal pathway gene activity in transcriptomic profiles of CLL cells following Tnv-6-treatment (n = 5). Negative values reflect down-regulation of gene expression

From: Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6

Gene

fold change

p value

aryl hydrocarbon receptor nuclear translocator

1.58

0.038

calnexin

1.58

<0.001

calpain 10

1.44

0.032

chromatin modifying protein 2B

1.76

0.001

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

2.7

0.028

cystatin B (stefin B)

3.17

0.008

cystinosis, nephropathic

2.15

0.004

DnaJ (Hsp40) homolog, subfamily B, member 9

1.55

0.018

Fas (TNFRSF6)-associated via death domain

−1.63

0.033

galactosamine (N-acetyl)-6-sulfate sulfatase

−1.52

0.044

hexosaminidase A (alpha polypeptide)

2.08

0.017

inositol hexaphosphate kinase 1

1.48

0.027

lysosomal-associated membrane protein 1

2.54

<0.001

lysosomal-associated membrane protein 2

1.8

0.027

Niemann-Pick disease, type C2

2.25

0.017

optineurin

2.61

0.003

phosphoinositide-3-kinase, class 3

1.17

0.0248

unc-51-like kinase 3 (C. elegans)

1.53

<0.001

upstream transcription factor 2, c-fos interacting

1.73

0.011

vacuolar protein sorting 41 (yeast)

1.34

0.042

Back to article page