Figure 3
From: Visualizing Brain Inflammation with a Shingled-Leg Radio-Frequency Head Probe for 19F/1H MRI
In Vivo 19F Quantification in an EAE mouse Brain using Single Voxel 19F Spectroscopy.
EAE was induced in SJL/J mice and 160 nm 19F-rich nanoparticles (40 μmoles 19F) were administered on the first signs of neurological symptoms. (A) Horizontal and (C) sagittal slices identifying lesions in the cerebellum; dotted box depicts the location of the 3 mm3 PRESS voxel around the lesion of interest within the cerebellum. (B) 19F MRS spectrum of the PRESS voxel in the cerebellum. (D) Horizontal and (F) sagittal slices identifying lesions in the cortex; dotted box depicts the location of the 3 mm3 PRESS voxel around the hypointense lesion within the cortex. (E) 19F MRS spectrum of the PRESS voxel in the cortex.
