Figure 7 | Scientific Reports

Figure 7

From: Hirsutella sinensis mycelium suppresses interleukin-1β and interleukin-18 secretion by inhibiting both canonical and non-canonical inflammasomes

Figure 7

Schematic model for the reduction of IL-1β and IL-18 secretion in LPS-primed and ATP-stimulated macrophages treated with HSM.

The HSM extract down-regulated P2X7R expression, ROS production, NLRP1 expression and caspase-1 and caspase-4 activation, which together inhibited the secretion of IL-1β and IL-18. TLR4: Toll-like receptor 4.

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