Figure 1
From: Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice
Intracardiac injection of rAAV9 with SynI promoter leads to widespread gene transduction of neprilysin in the brain.
Brain sections from intact wild-type mice (a), intact neprilysin-deficient mice (b) and neprilysin-deficient mice 14 days after intracardiac injection of 4 × 1011 genome vectors of rAAV9-SynI::NEPWT (c) or rAAV9-SynI::NEPMT (d). Scale bars, 200 μm.
