Table 5 Effects of the HMGA1 rs146052672 variant on insulin resistance

From: A polymorphism of HMGA1 is associated with increased risk of metabolic syndrome and related components

Italian population

Units

Wild-Type

Carrier

P

Number of subjects

n

3,169

172

 

Basal insulin in μU/mL

mean ± SD

9.8 ± 7.3

12.6 ± 7.9

<0.001

FPG in mg/dL

mean ± SD

104.3 ± 39.2

118.1 ± 42.4

<0.001

Number of subjects with FPG ≥ 100 mg/dL

n (%)

807 (24.5)

83 (48.3)

<0.001

HOMA2-B%*

mean ± SD

94.7 ± 53.3

99.4 ± 66.2

0.561

HOMA2-S%†

mean ± SD

119.1 ± 73.5

82.4 ± 51.7

<0.001

HOMA2-IR‡

mean ± SD

1.3 ± 1.0

1.7 ± 1.0

<0.001

Number of subjects with HOMA2-IR ≥ 1.8

n (%)

761 (24.0)

72 (41.9)

<0.001

  1. Linear regression analysis was used for assessing the effect of the HMGA1 variant on HOMA-IR, adding age, gender and BMI as covariates.
  2. 2-tailed Fisher exact test was used for comparisons of proportions.
  3. FPG, fasting plasma glucose.
  4. *Homeostatic model assessment method 2 for beta cells function.
  5. †Homeostatic model assessment method 2 for insulin sensitivity.
  6. ‡Homeostatic model assessment method 2 for insulin resistance.
  7. All HOMA2 values have been log-transformed to better approximate a normal distribution.
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