Figure 1 | Scientific Reports

Figure 1

From: A choline derivate-modified nanoprobe for glioma diagnosis using MRI

Figure 1

Synthetic route for the nanoprobes and their targeting strategies.

(a) DGL and CD were linked using MAL-PEG3.5K-NHS. Paramagnetic Gd3+ ions were conjugated to DP or DPC using p-SCN-Bn-DTPA. (b) The DP-DTPA-Gd nanoprobe accumulated in glioma via the EPR effect, whereas the DPC-DTPA-Gd nanoprobes could also enter the glioma via choline transporters, which are on brain capillary endothelial cells and glioma cells.

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