Figure 1 | Scientific Reports

Figure 1

From: Single molecule unfolding and stretching of protein domains inside a solid-state nanopore by electric field

Figure 1

(a) Schematic showing the expected protein states in relation to the principal sensing element, a 15 nm solid-state nanopore, drilled in a 50 nm thick silicon nitride membrane.(b) Crystal structure for the SAP97 PDZ2 domain. PDB CODE: 2X7Z. (c) Finite element simulations showing the electric field plotted as a function of distance from pore center; pore dimensions: 15 nm diameter, 50 nm thick membrane. This was performed over the range of 200-800 mV in which the effects on protein folding are investigated.

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