Figure 1
CD146EC-KO mice have less severe EAE than wild type mice.
(a) Wild type (WT) and CD146EC-KO mice (n = 11 mice per group) have a similar time of onset and incidence of EAE following immunization. (b) CD146EC-KO mice had lower mean clinical scores than WT mice (n = 11 mice per group). (c) Fewer CD146EC-KO mice had severe EAE (a clinical score ≥3) compared to the WT group (p < 0.01). (d) Luxol fast blue staining of spinal cord sections from CD146EC-KO and WT mice with EAE, showing inflammatory lesions (arrows) and demyelinated areas (n = 5 mice/group, 15 lesions/mouse). Scale bar, 200 μm.
