Figure 4 | Scientific Reports

Figure 4

From: IL-6 activated integrated BATF/IRF4 functions in lymphocytes are T-bet-independent and reversed by subcutaneous immunotherapy

Figure 4

IL-2 expression is increased in the lung of T-bet(−/−) asthmatic mice.

(a) Increased IL-2 protein expression in the supernatants of lung cells isolated from T-bet(−/−) asthmatic mice and cultured with α-CD3 and OVA (500 μg/ml) for 24 hours as indicated. (b) Decreased CD4+CD25+Foxp3+ Treg cells in T-bet(−/−) mice sensitized and challenged with OVA as described in Figure 1 and after flow cytometric analysis. Students t test was used to calculate statistical significances. * P ≤ 0.05, ** P ≤ 0.01, *** P ≤ 0.001. Results are expressed as mean ± s.e.m.

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