Figure 2
From: InterMOD: integrated data and tools for the unification of model organism research
Cross species analysis of pathways.
An image from part of the FlyMine report page for the Drosophila melanogaster forkhead gene. The rows list KEGG or Reactome pathway names. A "Yes" in the FlyMine column links to the corresponding FlyMine pathway report page. A "Yes" in the other columns indicates that an orthologue in another InterMine database shares the same pathway, with a link to the pathway report page in that database. When the web page loaded, the Drosophila forkhead gene was mapped to the genes Foxa1, Foxa2 and Foxa3 in rat, mouse and human, HCM1 in yeast and lin-31 in C. elegans using mappings from TreeFam. The datasets from rat (RatMine) and human (metabolicMine, unpublished) associate the orthologs with mature-onset diabetes and highlight their role in the regulation of beta-cell development. Further pathways via FlyMine indicate that human Reactome supports roles in pancreatic cell development.
