Figure 1 | Scientific Reports

Figure 1

From: Microtubule Alterations Occur Early in Experimental Parkinsonism and The Microtubule Stabilizer Epothilone D Is Neuroprotective

Figure 1

Treatment paradigm underlines early alterations.

(a) Biochemical analyses of striatal dopamine, DOPAC and HVA levels in C57Bl mice injected with saline or MPTP (30 mg/kg, i.p., single injection or 20 mg/kg, i.p., × 3, 2 h apart) and killed 12 or 72 hours later (mean ± S.E.M., n = 8–10 mice per group). *P < 0.05; one-way ANOVA, Dunnett post hoc versus saline-injected mice. (b) Immunoblot of TH levels in lysates of the corpus striatum and substantia nigra of mice injected with saline or MPTP as in a. (c) Densitometric analyses of immunoblot reported in b (mean ± S.E.M., n = 8–10 mice per group). *P < 0.05; one-way ANOVA, Dunnett post hoc test versus saline-injected mice. hpi = hours post last injection of MPTP.

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