Figure 3 | Scientific Reports

Figure 3

From: Microtubule Alterations Occur Early in Experimental Parkinsonism and The Microtubule Stabilizer Epothilone D Is Neuroprotective

Figure 3

MPTP treatment increases the βIII tubulin isotype.

(a) Immunoblots of actin, α-tubulin, β-tubulin and βIII tubulin in lysates of striatum of mice treated as in Fig. 1. (b) Densitometric analyses of immunoblot reported in a (mean ± S.E.M., n = 4–6 individuals per group). *P < 0.05; one-way ANOVA, Dunnett post hoc test versus saline-injected mice. (c) Immunoblot of actin, α-tubulin, β-tubulin and βIII tubulin in lysates of substantia nigra of mice treated as in Fig. 1. (d) Densitometric analyses of immunoblot reported in c (mean ± S.E.M., n = 4–6 individuals per group). *P < 0.05; one-way ANOVA, Dunnett post hoc test versus saline-injected mice. hpi = hours post last injection of MPTP.

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