Figure 2 | Scientific Reports

Figure 2

From: Kidney tubular β-catenin signaling controls interstitial fibroblast fate via epithelial-mesenchymal communication

Figure 2

Loss of tubular β-catenin does not affect fibrosis-related gene expression.

(a through d) Tubule-specific ablation of β-catenin exhibited little effect on renal expression of major fibrosis-related genes including fibronectin (a), collagen III (b), TGF-β1 (c) and connective tissue growth factor (CTGF) (d). No significant difference was found between Ksp-β-cat-/- and control mice. (e) Representative Western blot analyses show protein expression of fibronectin and PAI-1. (f, g) Relative levels of renal fibronectin (f) and PAI-1 (g) in Ksp-β-cat-/- and control mice at 7 days after UUO. No significant difference was found between Ksp-β-cat-/- and control mice.

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