Figure 6 | Scientific Reports

Figure 6

From: Kidney tubular β-catenin signaling controls interstitial fibroblast fate via epithelial-mesenchymal communication

Figure 6

Loss of tubular β-catenin reduces MMP-7 expression in obstructive nephropathy.

(a) Quantitative determination of MMP-7 mRNA expression in obstructed kidneys by qRT-PCR. Data are presented as fold induction over sham. **P < 0.01 versus control mice. (b) Representative RT-PCR showed a marked reduction of MMP-7 mRNA expression in the obstructed kidneys of Ksp-β-cat-/- mice at 7 days after UUO. (c, d) Immunohistochemical staining showed MMP-7 protein expression and localization. Representative micrographs showed MMP-7 staining in control and Ksp-β-cat-/- kidneys at 7 days after UUO. Yellow arrows indicate renal tubules. Scale bar, 50 μm.

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