Table 1 Very low fertility of male homozygous (null) KO and wild-type mice from heterozygous (null) KO parents

From: Antioxidant enzyme, 3-mercaptopyruvate sulfurtransferase-knockout mice exhibit increased anxiety-like behaviors: a model for human mercaptolactate-cysteine disulfiduria

  

Offspring number/parent

Mouse

Sex

Heteroa

Homob

Homozygous KO

Male

0.25

3.10

 

Female

0.75

1.80

Heterozygous KO

Male

1.25

-

 

Female

2.25

-

Wild-type

Male

0.25

-

 

Female

0.25

-

  1. aMating between heterozygous (null) KO mice (Cre−).
  2. bmating between homozygous (null) KO mice (Cre−). We obtained offspring from 4 heterozygous (null) KO parents in comparison with those from 10 homozygous (null) KO parents during a 5-month breeding trial.
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