Figure 5
Vascular location of Aβ plaques in brain of CRND8 transgenic mice.
(A) CRND8 transgenic or WT mice at the age of 18 weeks were sacrificed for immunostaining with anti-Aβ40 or anti-Aβ42 specific antibodies. Arrows point to Aβ plaques. Size bar = 0.2 mm. (B) Immunohistochemical double staining of the cortex of CRND8 transgenic or WT mice with anti-Aβ40 or anti-Aβ42 specific antibodies in combination with an anti-mouse CD31 or with a mouse anti-human α-SMA antibody. Arrows point to vasculature-associated Aβ plaques.
