Figure 4
Concentration polarization of ox-LDL occurs on the surface rabbit thoracic aorta.
(A) and (B) show water filtration rate (vw, about 12.9 × 10−6 cm/s) and relative ox-LDL wall concentration (cwa/c0, always higher than 1.0), indicating that concentration polarization of ox-LDL also occurred on the surface rabbit thoracic aorta. (C) Concentration polarization of ox-LDL decreases HSPG expression and increases LOX-1 expression and induces activation of autophagy (expression of LC3, Beclin-1 and Atg5) and apoptosis (expression of Cytochrome c, Bax, Bcl-2 and Bcl-xL). The samples were derived from the same experiment and gels/blots were processed in parallel. Bar graphs represent data in mean ± SD based on 7 experiments, * P < 0.05 vs. control.
