Figure 4
From: Differential epigenome-wide DNA methylation patterns in childhood obesity-associated asthma
(a). Network of differentially methylated molecules in obese asthmatics compared to normal-weight asthmatics. Genes encoding for molecules in red nodes are hypomethylated in obese asthmatics while those in green nodes are hypermethylated relative to normal weight asthmatics. (b). Network of differentially methylated molecules in obese asthmatics compared to obese non-asthmatics. Genes encoding for molecules in red are hypomethylated in obese asthmatics while those in green are hypermethylated relative to obese non-asthmatics. The nodal relationships indicated in solid lines denote direct while those in dashed lines denote indirect interactions. The shape of each node denotes the molecule class: horizontal ovals are transcription factors, vertical ovals are transmembrane receptors, horizontal diamonds are peptidases, vertical diamonds are enzymes, squares are growth factors, horizontal rectangles are nuclear receptors, vertical rectangles are ion channels, inverted triangles are kinases and circles are “other” molecules. (c). Network of differentially methylated molecules in obese asthmatics compared to healthy controls. Genes encoding for molecules in red are hypomethylated in obese asthmatics while those in green are hypermethylated relative to healthy controls. The nodal relationships indicated in solid lines denote direct while those in dashed lines denote indirect interactions. The shape of each node denotes the molecule class: horizontal ovals are transcription factors, vertical ovals are transmembrane receptors, horizontal diamonds are peptidases, vertical diamonds are enzymes, squares are growth factors, horizontal rectangles are nuclear receptors, vertical rectangles are ion channels, inverted triangles are kinases and circles are “other” molecules.
