Figure 2
From: Noninvasive fractal biomarker of clock neurotransmitter disturbance in humans with dementia
More disrupted fractal activity correlations in dementia patients with more reduced neurotransmitter in the SCN.
(A) Δα = α1 − α2 was negatively correlated with the number of vasopressin-positive SCN neurons after adjusting for the effect of the number of neurotensin-positive SCN neurons. (B) Δα was correlated with the number of neurotensin-positive SCN neurons after adjusting for the effect of the number of vasopressin-positive SCN neurons. Results in (A) and (B) were obtained from 13 subjects with dementia (10 with AD) using a regression model in which the two SCN neurotransmitters (vasopressin and neurotensin) were included as two factors (See Model 1 in Table 1). (C) α1-α2 was correlated with the number of vasopressin-positive SCN neurons after adjusting for the effect of AD severity as characterized by the plaque density from occipital Bielschowsky stain. (D) α1-α2 was correlated with the AD severity after adjusted for the effect of the number of vasopressin-positive SCN neurons. Results in (C) and (D) were obtained from 13 subjects with dementia (9 with AD) using a regression model in which vasopressin neuronal density and plaque density were included as two factors (see Model 2 in Table 1).
