Figure 6
Activation of anticancer prodrugs by the DMAE-SS-PRX/β-gal complexes.
(A) Chemical structures of 5-fluorouridine-5′-O-β-d-galactopyranoside (5-FUR-β-gal) and 5-fluorouridine (5-FUR). (B) Relative viability of HeLa cells incubated for 24 h with 5-FUR-β-gal (open circles) and 5-FUR (closed circles). (C) Relative viability of HeLa cells treated with Xfect/β-gal, cleavable DMAE-SS-PRX/β-gal complexes (N/C 2) and non-cleavable DMAE-PRX/β-gal complexes (N/C 2) at various β-gal concentrations for 24 h, followed by incubation with or without 5-FUR-β-gal (100 μM) for 24 h. Data are expressed as the means ± SD (n = 6).
