Figure 9
From: Spatio-temporal analysis of type 2 diabetes mellitus based on differential expression networks
Our temporal analysis supports that rising of insulin secretion is the root cause of insulin resistance in diabetes.
The peak of insulin resistance (characterized by Irs1) occurring at D16 lags behind the peak of insulin secretion occurring at D12. This fact supports the model of b-cell secretion of insulin leading to hyperinsulinemia and causing insulin resistance41.
