Table 1 Expression profile of antiviral genes from public microarray database
From: Induction of antiviral genes by the tumor microenvironment confers resistance to virotherapy
Gluck Breast (Invasive Breast Carcinoma vs. Normal = 154 vs. 4) | TCGA Breast (Invasive Breast Carcinoma vs. Normal = 76 vs. 61) | Bonome Ovarian (Ovarian Carcinoma vs. Normal = 185 vs. 10) | TCGA Ovarian (Ovarian Serous Cystadenocarcinoma vs. Normal = 509 vs. 8) | |||||
|---|---|---|---|---|---|---|---|---|
GENE | P-value | FC* | P-value | FC* | P-value | FC* | P-value | FC* |
IRF7 | 0.002 | 1.369 | 1.29E-23 | 2.764 | n.a. | n.a. | n.a. | n.a. |
IRF9 | 0.003 | 1.634 | 2.22E-10 | 1.765 | 1.49E-07 | 2.04 | 0.141 | 1.165 |
MX1 | 0.002 | 1.935 | 1.36E-6 | 1.865 | 0.013 | 1.208 | 0.009 | 1.613 |
MX2 | 0.19 | 1.213 | 2.25E-11 | 2.004 | 4.61E-05 | 1.664 | 3.12E-04 | 3.933 |
OAS1 | 0.001 | 1.939 | 6.70E-14 | 2.379 | 0.012 | 1.528 | 1.25E-04 | 3.226 |
OAS2 | 1.64E-5 | 2.059 | 1.65E-23 | 4.788 | 3.29E-04 | 1.495 | 3.46E-04 | 2.490 |
STAT1 | 6.28E-4 | 1.843 | 2.66E-18 | 2.798 | 0.999 | −1.587 | 1.87E-06 | 2.999 |
STAT2 | 7.74E-4 | 2.196 | 3.97E-7 | 1.295 | 3.89E-9 | 1.519 | 1.50E-4 | 1.262 |
JAK1 | 0.940 | −1.404 | 0.681 | −1.061 | 1.000 | −2.923 | 1.000 | −1.316 |
TYK2 | 0.012 | 1.502 | 1.84E-11 | 1.609 | 0.024 | 1.168 | 3.66E-4 | 1.226 |
IFNAR1 | 0.677 | −1.102 | 0.028 | 1.298 | 0.862 | −1.072 | 0.976 | −1.093 |
IFNAR2 | 0.003 | 1.339 | 0.093 | 1.141 | 0.994 | −1.230 | 0.308 | 1.075 |
