Table 2 The effect of bursting in the input reactions on the eight chemical systems shown in Table I. The sign of
determines whether the model exhibits Case III or Case II behaviour (see Fig. 1), i.e., the necessary conditions for burstiness to promote or destroy noise-induced oscillations respectively (fourth and sixth columns of the table). Determining whether input bursting can in fact promote or destroy oscillations requires the full condition that θ1 is large enough; the columns ‘BIO Observed’ and ‘BDO Observed’ are the results of our numerical investigation to this end (see text for details). The upper four circuits feature input burstiness in only one species, the lower four feature input burstiness in both species. Note that ai are positive constants
From: Effects of bursty protein production on the noisy oscillatory properties of downstream pathways
Bursts Induce Oscillations (BIO) | Bursts Destroy Oscillations (BDO) | |||||
|---|---|---|---|---|---|---|
Model |
| Feedback Motif (J) | Necessary conditions (Case III) | BIO Observed? | Necessary conditions (Case II) | BDO Observed? |
Brusselator | a1 (η1 − 1) |
| ✗ | N/A | ✓ | ✓ |
Trimerization | −a2 (η1 − 1) |
| ✓ | ✓ | ✗ | N/A |
One Gene Model A | −a3 (η1 − 1) |
| ✓ | ✓ | ✗ | N/A |
One Gene Model B | a4 (η1 − 1) |
| ✗ | N/A | ✓ | ✗ |
Autocatalysis | a5 [(Λ1 + 1) + Λ1η2 − (2Λ1 + 1) η1] |
| ✓ | ✓ | ✓ | ✓ |
Two Gene Model A | a6 (η2 − η1) |
| ✓ | ✗ | ✓ | ✗ |
Two Gene Model B | a7 (η2 − η1) |
| ✓ | ✓ | ✓ | ✓ |
Two Gene Model C | a8 (η2 − η1) |
| ✓ | ✗ | ✓ | ✗ |
determines whether the model exhibits Case III or Case II behaviour (see