Figure 3

Fitted time-trends (solid lines) and 95% pointwise confidence intervals (dashed lines) for repeated measurements of log-transformed α-syn plasma concentrations obtained from patients with PD, plotted as time since onset of initial symptoms.

P-values refer to Wald tests of the hypothesis of no time-trend. Note that the level of phosphorylated α-syn does not change significantly with disease progression, whereas total α-syn shows a significant increasing time-trend.