Table 1 Pearson's Correlation Co-efficient for Co-localisation between LRP/LR and AD relevant proteins

From: Anti-LRP/LR specific antibodies and shRNAs impede amyloid beta shedding in Alzheimer's disease

AD relevant proteins

IF

Confocal

LRP/LR + APP

0.862

0.20

LRP/LR + β-secretase

0.915

0.53

LRP/LR + γ-secretase

0.938

0.57

LRP/LR + VLA6

0.583

-

LRP/LR + GFP

-

−0.51

  1. The Pearson's Correlation co-efficient was employed to determine the degree of co-localisation between proteins of interest, where 1 indicates complete co-localisation and −1 is indicative of no co-localisation. The co-efficient was calculated for LRP/LR and AD relevant proteins APP, β- and γ-secretase respectively employing both Immunofluorescent Microscopy and Confocal Microscopy (employing fluorescently tagged proteins of interest).
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