Figure 2 | Scientific Reports

Figure 2

From: Pharmacologically Controlled Protein Switch for ON-OFF Regulation of Growth Factor Activity

Figure 2

Characterization of inducible dimer- and monomerization and receptor binding affinity.

(a) Inducible dimer- and monomerization of the switch. VEGFSWITCH was incubated at room temperature without or with coumermycin for 60 min, or with coumermycin for 30 min followed by 30 min with novobiocin added. The resulting molecular weights were determined using size exclusion chromatography. (b) Receptor-ligand binding affinity. Saturation curve for the binding of the different VEGFSWITCH variants to VEGFR2.

Back to article page