Table 3 Pooled odds ratio for COPD susceptibility, heterogeneity and publication bias in meta-anlysis: comparison of alleles and genotypes

From: Genetic Polymorphism of Matrix Metalloproteinase Family and Chronic Obstructive Pulmonary Disease Susceptibility: a Meta-analysis

    

Heterogeneity

Publication bias

Comparison

Study number

OR (95% CI)

P value

I2

P heterogeneity

Begg

Egger

MMP1 -1607 1G/2G (rs1799750)

       

1G vs. 2G

12

0.99 (0.89, 1.10)

0.81

53%

0.01

0.945

0.980

1G1G + 1G2G vs. 2G2G

12

1.03 (0.86, 1.22)

0.76

58%

0.007

1

0.352

1G1G vs. 1G2G + 2G2G

12

0.99 (0.81, 1.21)

0.94

58%

0.006

0.244

0.274

1G1G vs. 2G2G

12

0.93 (0.77, 1.12)

0.44

38%

0.08

0.732

0.568

MMP3 -1171 5A/6A (rs35068180)

       

5A vs. 6A

5

0.88 (0.61, 1.27)

0.50

71%

0.009

0.806

0.441

5A5A + 5A6A vs. 6A6A

4

0.92 (0.58, 1.46)

0.73

58%

0.07

0.089

0.100

5A5Avs. 5A6A + 6A6A

4

0.91 (0.58, 1.41)

0.66

50%

0.11

0.089

0.049

5A5A vs. 6A6A

3

1.18 (0.76, 1.82)

0.46

0%

0.42

0.296

0.210

MMP9 -1562 C/T (rs3918242)

       

C vs. T

12

0.83 (0.62, 1.12)

0.22

79%

<0.0001

0.732

0.953

CC + CT vs. TT

11

0.75 (0.45, 1.24)

0.26

22%

0.24

0.533

0.100

CC vs. CT + TT

12

0.80 (0.57, 1.14)

0.22

81%

<0.0001

0.837

0.732

CC vs. TT

11

0.71 (0.40, 1.24)

0.23

31%

0.15

0.533

0.082

MMP12 -82 A/G (rs2276109)

       

A vs. G

6

0.98 (0.80, 1.20)

0.82

44%

0.11

0.133

0.066

AA + AG vs. GG

4

1.14 (0.59, 2.20)

0.69

0%

0.70

1

0.862

AA vs. AG + GG

6

0.96 (0.76, 1.21)

0.72

52%

0.07

0.452

0.078

AA vs. GG

4

1.17 (0.61, 2.25)

0.64

0%

0.71

1

0.938

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