Figure 8
Depletion of mucosally-adherent Clostridium bacteria mediates the effects of VSL#3 on dysplasia/tumorigenesis.
(a) Mediation analysis by linear models was performed between VSL#3 status, dysplasia score and each OTU in the stool or mucosally-adherent microbiota. Results for OTU #199 are shown. P < 0.10 was used as cutoff. The Benjamini and Hotchberg FDR adjustment was applied for multiple testing correction (model 2). A detailed description of the models is provided in Materials and Methods. (b) OTU #199, assigned to genus Clostridium, median log-normalized abundance + SEM. FDR-corrected P-value is shown, uncorrected P-value = 0.0002. SPF n = 5, SPF + VSL#3 n = 4.
