Figure 2

Dixon plot analysis of inhibition of estradiol 3-O-glucuronidation in the recombinant UGT1A1.

Inhibitory effects of oleic acid (A), linoleic acid (B) and DHA (C) on estradiol 3-O-glucuronidation were analyzed. Filled circles, open circles and open triangles are the data obtained with 5, 10 and 20 μM estradiol, respectively.