Figure 1
From: Genome-wide methylated CpG island profiles of melanoma cells reveal a melanoma coregulation network
Characterization of genome-wide methylation patterns in melanoma cell lines.
(A) The overall workflow and results of next-generation sequencing and analysis of MBD2-pulldown DNA. (B) Frequency distributions of sizes of the MBD2-pulldown DNA across five cell lines. The methylated regions were defined by MACS peak calling of the MBD2-pulldown DNA against input (non-enriched) DNA. (C) & (D) Venn diagram of the number of MBD2-pulldown regions shared or unique among the various cell lines. (E) Venn diagram describing the number of MBD2-pulldown DNA regions partitioned among various cell lines, which defines a unique set of stage IV specific MBD2-pulldown DNA regions. (F) Genome-wide distribution of differential methylated regions (as defined as the MBD2-pulldown DNA). The outermost circle displays the human chromosomes. The inner circles represent the genome-wide distribution of MBD2-pulldown DNA. The height of the histogram bins indicates the density of methylated regions. From the inner most circle, which represents the distribution of MBD2-pulldown DNA in 5AzadC treated WM1552C (black), the circles from inside going outside represent HEM-1 (orange), WM793B (blue), WM1552C (green), A375 (red) and SKEML2 (red).
