Figure 4
From: Genome-wide methylated CpG island profiles of melanoma cells reveal a melanoma coregulation network
CpG methylation status near SNOR-10 gene in different patient samples.
(A) depicts the results obtained with next-generation sequencing of MBD2-enriched DNA in the five cell lines, plus those in WM1552C cells treated with 5AzadC and those in the input DNA. (B) A region between −249 bp and −31 bp of the TSS of SNORD-10 is shown magnified. Methylation status of this region in the DNA obtained from various metastatic melanoma patient samples or in non-melanoma nevi was determined by bisulfite sequencing (see Methods). Each box is a CpG; open boxes are unmethylated, filled boxes are methyl CpG sequences. Numbers at the right represent the number of methyl CpG detected in the region corresponding to each row (independent sequence analysis).
