Scientific Reports

Table 1 Treatment response, EGFR status and mutation status of GC PDX models

From: A subset of gastric cancers with EGFR amplification and overexpression respond to cetuximab therapy

	Non-Responders																Responders
	GA	GA	GA	GA	GA	GA	GA	GA	GA	GA	GA	GA	GA	GA	GA	GA	GA	GA	GA	GA	P value (non- vs. responders)
Model ID	0114	2140	0006	0119	0139	0138	0037	0033	0023	0080	0151	0044	0098	0060	0055	0025	0022	0046	0075	0152	P value (non- vs. responders)
ΔT/ΔC	1.744	1.492	1.42	0.934	0.912	0.898	0.881	0.811	0.781	0.748	0.717	0.687	0.58	0.488	0.41	0.305	−0.071	−0.078	−0.098	−0.121	0.002
Copy Number
EGFR (SNP6 + PICNIC)	6	NE*	7	5	5	5	5	5	4	6	NE	5	5	5	5	NE	7	7	8	15	0.002
EGFR (q-PCR)	5.1	3.8	2.1	2.1	4.8	2.7	3.7	3.9	1.9	3.7	1.4	2.1	3.7	3.1	2.9	2.1	5.4	4.3	4.6	1040.9	0.008
EGFR (FISH)	1.9	2.3	2.0	2.0	3.0	2.6	2.7	2.4	2.1	2.4	2.1	2.4	2.5	2.0	2.0	2.4	2.8	2.3	5.8	>15	0.029
CEP7 (FISH)	1.9	2.2	2.1	2.0	2.7	2.0	2.3	2.0	2.5	2.1	2.2	2.3	2.1	2.2	2.0	2.3	2.0	2.3	5.2
Ratio (EGFR/CEP7)	0.96	1.04	0.97	1.03	1.09	1.29	1.16	1.21	0.83	1.16	0.93	1.03	1.2	0.91	1.01	1.05	1.39	1.03	1.12	>15	0.099
mRNA
EGFR U219 intensity	2.9	NE	3.3	3.6	2.9	2.3	2.5	2.4	2.5	2.8	3.6	3.1	4.3	4.2	4	3.8	6.5	6.9	5.8	10.5	0.003
EGFR Relative Intensity	0	0.1	0.08	0.14	0	0	0	0.02	0.02	0.02	0.2	0.13	0.07	0.13	0.1	0.1	0.81	0.62	0.5	13	0.002
Protein
EGFR IHC Score	0	2	1	1	0	0	0	0	0	1	1	1	1	1	2	0	3	3	3	3	0.002
Mutation
EGFR\|Exon18;19;20;21	WT	NE	WT	WT	WT	WT	WT	WT	WT	WT	WT	WT	WT	WT	WT	WT	WT	WT	WT	WT
k-RAS\|Exon2;3;4	WT	NE	WT	WT	G13D	WT	WT	WT	WT	WT	WT	WT	WT	WT	WT	WT	WT	WT	WT	WT
BRAF\|Exon15	WT	NE	WT	WT	WT	WT	WT	WT	WT	WT	WT	WT	WT	WT	WT	WT	WT	WT	WT	WT
c-MET\|Exon14;16;17;18;19;21	WT	NE	WT	WT	WT	WT	WT	WT	WT	WT	WT	WT	WT	WT	WT	WT	WT	WT	WT	WT
PIK3CA\|Exon1;9;20	WT	NE	WT	WT	WT	WT	WT	WT	WT	WT	WT	Del* 327–329	G545Y	WT	WT	WT	WT	WT	WT	WT

These model are sorted by the ratio of ΔT/ΔC and the final four are responders.* Del: deletion; NE: not evaluable.

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