Figure 1: JAK1 truncating mutations found in the TCC human tumors and CCLE cancer cells.

Schematic representation of JAK1 protein and the truncating mutation sites identified in the TCC tumors and CCLE cells. Vertical bars above JAK1 are proportional to the numbers of mutations found in the TTC and CCLE datasets. * indicates positions of nonsense mutations. Horizontal bars end at the position of stop codons.