Figure 3: JAK1 deficient cancer cells are defective in the IFN-γ-stimulated LMP2/TAP1 antigen-processing machinery pathway. | Scientific Reports

Figure 3: JAK1 deficient cancer cells are defective in the IFN-γ-stimulated LMP2/TAP1 antigen-processing machinery pathway.

From: JAK1 truncating mutations in gynecologic cancer define new role of cancer-associated protein tyrosine kinase aberrations

Figure 3

(a) Cell lysates from 6 cell lines were analyzed by immunoblotting with an anti-JAK1 antibody. Position of the 130-kDa full-length JAK1 is indicated. Other bands appear on the immunoblot are unknown non-specific immunoreactivities. (b–c) Cells were treated with IFNγ for the indicated time. Cell lysates were analyzed by immunoblotting for IFN-γ-induced pSTAT1, IRF1, LMP2, and TAP1.

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