Figure 4: Analysis of IFN-γ-induced LMP2- and TAP1-promoter activities. | Scientific Reports

Figure 4: Analysis of IFN-γ-induced LMP2- and TAP1-promoter activities.

From: JAK1 truncating mutations in gynecologic cancer define new role of cancer-associated protein tyrosine kinase aberrations

Figure 4

(a) Comparison of IFN-γ-induced, IRF1-dependent LMP2 and TAP1-promoter activities in GYN cancer cell lines. The basal LMP2-Luc or TAP1-Luc activity, respectively, in Hela cells was set as 1 for comparison of Luc activities. Data were from two independent experiments performed in duplicate (n = 4). (b) JAK1 mutation cells were transfected with pCMV-JAK1 or the control vector and LMP2/TAP1-promoter reporter plasmids as in (a). IFN-γ-stimulated LMP2- and TAP1-promoter luciferase activities were assayed. *, p < 0.05 by the Mann-Whitney test. Differences in the basal LMP2- and TAP1-luciferase activities between cells transfected with pCMV-JAK1 and the control vector were p < 0.05 in all cell lines.

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