Table 2 Summary of meta-analysis of association of CDKAL1 gene rs7756992 A/G gene polymorphism and type 2 diabetes mellitus (T2DM)

From: CDKAL1 gene rs7756992 A/G polymorphism and type 2 diabetes mellitus: a meta-analysis of 62,567 subjects

Genetic model

Pooled OR (95% CI)

Z value

P value

Study number

T2DM size

control size

P heterogeneity( I2%)

Allelic genetic model

1.180(1.130–1.230)

7.68

1.60 × 10−14*

21

26120

36447

0.0001*(61.3%)

Caucasian subgroup

1.220(1.170–1.270)

9.51

5.85 × 10−22*

7

9005

18372

0.47(0%)

Asian subgroup

1.190(1.110–1.270)

5.09

3.58 × 10−7*

12

16765

16602

<0.0001* (73.3%)

African subgroup

1.070(0.960–1.190)

1.20

0.23

2

1350

1473

0.70(0%)

Recessive genetic model

1.510(1.380–1.660)

8.70

8.41 × 10−18*

21

26120

36447

<0.00001* (70.3%)

Caucasian subgroup

1.470(1.340–1.610)

8.15

4.22 × 10−16*

7

9005

18372

0.88(0%)

Asian subgroup

1.570(1.360–1.800)

6.26

3.85 × 10−10*

12

16765

16602

<0.00001* (81.9%)

African subgroup

1.420(1.040–1.940)

2.20

0.03*

2

1350

1473

0.19(42.2%)

Dominant genetic model

1.175(1.109–1.246)

5.41

6.30 × 10−8*

21

26120

36447

0.001* (56.4%)

Caucasian subgroup

1.239(1.176–1.305)

8.02

7.85 × 10−15*

7

9005

18372

0.439(0%)

Asian subgroup

1.173(1.068–1.289)

3.33

8.68 × 10−4*

12

16765

16602

<0.00001* (67.2%)

African subgroup

1.008(0.843–1.206)

0.09

0.927

2

1350

1473

0.212(35.8%)

Homozygous genetic model

1.400(1.282–1.530)

7.47

8.02 × 10−14*

21

26120

36447

<0.00001* (59.9%)

Caucasian subgroup

1.530(1.391–1.684)

8.72

5.81 × 10−18*

7

9005

18372

0.767(0%)

Asian subgroup

1.404(1.237–1.594)

5.25

1.52 × 10−7*

12

16765

16602

<0.00001* (70.9%)

African subgroup

1.058(0.840–1.332)

0.48

0.631

2

1350

1473

0.537(0%)

Heterzygous genetic model

1.101(1.040–1.166)

3.31

0.001*

21

26120

36447

0.007* (48.6%)

Caucasian subgroup

1.185(1.122–1.252)

6.04

1.54 × 10−9*

7

9005

18372

0.574(0%)

Asian subgroup

1.078(0.990–1.174)

1.74

0.083

12

16765

16602

0.012* (54.6%)

African subgroup

0.954(0.788–1.154)

0.49

0.626

2

1350

1473

0.103(62.4%)

  1. *P < 0.05.
  2. Abbreviations: T2DM: type 2 diabetes mellitus; CI: confidence interval; OR: odds ratio; T2DM size: the total number of T2DM cases; control size: the total number of control group; Allelic genetic model: G allele distribution frequency; recessive genetic model: GG vs. AA + AG; Dominant genetic model: AG + GG vs. AA; Homozygous genetic mode: GG vs. AA; Heterzygous genetic model: AG vs. AA; Additive genetic model: total G allele vs. total A allele.
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